João Carlos Degraf Muzzi Computational Oncology · Bioinformatics · Data Science

Publications & Academic Service

Peer-reviewed research, scientific collaboration, mentoring, and academic contributions across computational oncology, immunology, genetics, biotechnology, and data science.

Selected publications Full publication list Mentoring & supervision Academic service Scientific affiliations

Selected publications

Representative work in computational oncology, immunology, genetics, biotechnology, and diagnostics.

Distinct Transcriptional Programs Controlled by NR5A1 and β-Catenin in Adrenocortical Carcinoma

Medical Sciences, 2026

First-author study separating the transcriptional programs of the two regulatory axes and delimiting where their functional interplay is supported by the data.

DOI: 10.3390/medsci14040493

Steroidogenic Factor-1 regulates a core set of target genes to promote malignancy in adrenocortical carcinoma

European Journal of Endocrinology, 2025

First-author study integrating regulatory-network analysis, transcriptomic data, and experimental evidence.

DOI: 10.1093/ejendo/lvaf138 Explore impact →

Comprehensive Characterization of the Regulatory Landscape of Adrenocortical Carcinoma

Cancers, 2022

First-author study identifying transcription factors and prognostic regulatory targets.

DOI: 10.3390/cancers14215279

Steroid Phenotype Stratification Reveals Distinct HLA Expression Signatures

Cancers, 2026

Study of immune heterogeneity associated with steroid phenotypes in adrenocortical carcinoma.

DOI: 10.3390/cancers18020229 Explore impact →

Reconstructing the Origin and Demographic Expansion of the TP53 p.R337H Founder Variant in Brazil

Cancer Epidemiology, Biomarkers & Prevention, 2026

Population-genetics research on a clinically relevant Brazilian founder variant.

DOI: 10.1158/1055-9965.EPI-25-1148

Unraveling Immune-Related lncRNAs in Breast Cancer Molecular Subtypes

Frontiers in Oncology, 2021

Integrative analysis of immune-related non-coding RNAs across breast-cancer molecular subtypes.

DOI: 10.3389/fonc.2021.692170 Explore impact →

Full publication list

Complete scientific output, newest first, with peer-reviewed articles and preprints identified.

Peer-reviewed Medical Sciences · 2026
Distinct Transcriptional Programs Controlled by NR5A1 and β-Catenin in Adrenocortical Carcinoma João Carlos Degraf Muzzi; Bonald Cavalcante Figueiredo; Jean Silva de Souza Resende; Igor Samesima Giner; Mauro Antônio Alves Castro; Enzo Lalli DOI: 10.3390/medsci14040493
Preprint Preprint · 2026
Stratified Immune Profiling Uncovers Prognostic Heterogeneity Beyond MYCN Amplification and Age in Neuroblastoma Jessica M. Magno; João C. D. Muzzi; Jean S. S. Resende; Lana B. P. Querne; Larissa M. Alvarenga; Luciane R. Cavalli; Bonald C. Figueiredo; Mauro A. A. Castro DOI: 10.64898/2026.07.15.738570
Peer-reviewed Toxicon · 2026
Integrating epidemiological evidence and immunodiagnostic development for early diagnosis of Bothrops spp. envenomation in Brazil Mariana Fernandes Fonseca; Alessandra Becker-Finco; Bianca Prado-Costa; Guilherme Rabelo Coelho; Michele Marta Weber-Lima; João Carlos Degraf Muzzi; Isabella Gizzi Jiacomini; Martina Beltramino; Luciana Aparecida Freitas-de-Sousa; Patrícia Bianca Clissa et al. DOI: 10.1016/j.toxicon.2026.109022
Peer-reviewed Analysis & Sensing · 2026
A Multiepitope-Based Lateral Flow Assay for Leprosy Antibodies Cristiane Zocatelli-Ribeiro; Camila dos Anjos Proença; Ana Carolina da Rosa Nogarolli; Ana Fabiele Domakoski Trevisan; Thiago Neves Machado; João Carlos Degraf Muzzi; Larissa Magalhães Alvarenga; Juliana de Moura DOI: 10.1002/anse.202500121
Peer-reviewed Cancer Epidemiology, Biomarkers & Prevention · 2026
Reconstructing the Origin and Demographic Expansion of the TP53 p.R337H Founder Variant in Brazil Emilia Modolo Pinto; João Carlos Degraf Muzzi; José Andres Yunes; Bonald Cavalcante de Figueiredo; Raul C. Ribeiro; Gerard P. Zambetti DOI: 10.1158/1055-9965.EPI-25-1148
Peer-reviewed Toxicon · 2026
Influence of the ABO system on the hemolytic activity of medically relevant Loxosceles venoms in Brazil Martina Beltramino; Isabella Gizzi Jiacomini; Bianca Prado-Costa; Mariana Fernandes Fonseca; João Carlos Degraf Muzzi; Juliana Ferreira de Moura; João Carlos Minozzo; Alessandra Becker-Finco; Larissa M. Alvarenga DOI: 10.1016/j.toxicon.2026.108994
Peer-reviewed Cancers · 2026
Steroid Phenotype Stratification Reveals Distinct HLA Expression Signatures in Adrenocortical Carcinoma Igor S. Giner; Jean S. S. Resende; João C. D. Muzzi; José A. M. Barbuto; Enzo Lalli; Mauro A. A. Castro; Bonald C. Figueiredo DOI: 10.3390/cancers18020229
Peer-reviewed Histochemistry and Cell Biology · 2025
Stromal QSOX1 loss is a distinctive feature of colorectal cancer and correlates with tumor expansion Ângela C. Michalichyn; Heitor C. Bonilha; Lúcia de Noronha; Caroline T. Saad; João C. D. Muzzi; Johannes A. Eble; Silvio M. Zanata; Camila Marconi; Lia S. Nakao DOI: 10.1007/s00418-025-02451-9
Peer-reviewed European Journal of Endocrinology · 2025
Steroidogenic factor-1 regulates a core set of target genes to promote malignancy in adrenocortical carcinoma João C D Muzzi; Carmen Ruggiero; Mabrouka Doghman-Bouguerra; Maísa E Colodel; Jessica M Magno; Jean S S Resende; Nelly Durand; Juliana F de Moura; Larissa M Alvarenga; Luciane R Cavalli et al. DOI: 10.1093/ejendo/lvaf138
Peer-reviewed International Journal of Molecular Sciences · 2023
Steroidogenic Factor 1, a Goldilocks Transcription Factor from Adrenocortical Organogenesis to Malignancy Lauriane Relav; Mabrouka Doghman-Bouguerra; Carmen Ruggiero; João C. D. Muzzi; Bonald C. Figueiredo; Enzo Lalli DOI: 10.3390/ijms24043585
Peer-reviewed Cancers · 2022
Comprehensive Characterization of the Regulatory Landscape of Adrenocortical Carcinoma: Novel Transcription Factors and Targets Associated with Prognosis João C. D. Muzzi; Jéssica M. Magno; Jean S. Souza; Larissa M. Alvarenga; Juliana F. de Moura; Bonald C. Figueiredo; Mauro A. A. Castro DOI: 10.3390/cancers14215279
Peer-reviewed Frontiers in Endocrinology · 2021
Adrenocortical Carcinoma Steroid Profiles: In Silico Pan-Cancer Analysis of TCGA Data Uncovers Immunotherapy Targets for Potential Improved Outcomes DOI: 10.3389/fendo.2021.672319
Peer-reviewed Frontiers in Oncology · 2021
Unraveling Immune-Related lncRNAs in Breast Cancer Molecular Subtypes DOI: 10.3389/fonc.2021.692170
Peer-reviewed Applied Microbiology and Biotechnology · 2014
Phage-displayed peptides as capture antigens in an innovative assay for Taenia saginata-infected cattle DOI: 10.1007/s00253-014-5968-0

Mentoring & Supervision

I contribute to student and researcher development across medicine, computer science, bioinformatics, machine learning, transcriptomics, and computational oncology.

Current

Co-supervisor — PhD in Bioinformatics
Ongoing interdisciplinary project involving bioinformatics and computational data analysis.

Co-supervisor — Undergraduate Computer Science thesis
Machine learning applied to transcriptomic data. Ongoing.

Completed

Undergraduate research supervision in Medicine
Analysis of melanocortin 2 receptor expression in adrenocortical carcinoma.

Academic Service

Examination boards, teaching, and scientific service documented in my academic record.

Thesis & dissertation committees
  • Doctoral dissertation committee on machine learning and cardiometabolic risk.
  • Doctoral dissertation committee on humoral immune response in triple-negative breast cancer.
Other examination boards
  • Graduate-program candidate selection committee.
Courses taught and invited presentations
  • Learning R, 2023
  • Introduction to R Programming, 2022
  • Introduction to the R Language, 2020
  • Adult ACC Bioinformatics, pediatric adrenal tumor workshop, 2023
  • Brazilian Symposium on Bioinformatics, 2023
  • Big Data, bioinformatics, and georeferenced epidemiological research, 2023
Scientific and academic collaboration

Statistical design, analysis, interpretation, and visualization for multidisciplinary projects from other research centers, contributing to studies in colorectal cancer, snakebite diagnostics, leprosy, and other biomedical areas.

International research collaboration with the Institut de Pharmacologie Moléculaire et Cellulaire in France, through the Pelé Pequeno Príncipe Research Institute.

Scientific affiliations & research areas

Memberships and the research questions I currently work on.

Sigma Xi — Full MemberThe Scientific Research Honor Society · since 2025
ENS@T — MemberEuropean Network for the Study of Adrenal Tumours · since 2025
AIFOD — MemberAI for Developing Countries Forum · since 2025

Current research areas

  • Adrenocortical carcinoma and neuroblastoma
  • Transcriptional regulation and regulatory networks
  • Tumor immune profiling and HLA expression
  • Clinical prognosis and molecular stratification
  • Rare and pediatric tumors
  • TP53 founder variants and cancer genetics